发明名称 |
CHEMICALLY MODIFIED NALOXONE |
摘要 |
The invention relates to a small molecule drug naloxone that is chemically modified by covalent attachment of a water-soluble oligomer polyethylene glycol. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drugs not attached to the water-soluble oligomer. |
申请公布号 |
EA018427(B1) |
申请公布日期 |
2013.07.30 |
申请号 |
EA20100000994 |
申请日期 |
2004.12.16 |
申请人 |
NEKTAR THERAPEUTICS |
发明人 |
BENTLEY MICHAEL, D.;VIEGAS TACEY, X.;GOODIN RICHARD, R.;CHENG LIN;ZHAO XUAN |
分类号 |
A61K47/48;A61K31/765;A61K31/785;C08G65/08 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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