发明名称 |
METHODS OF TREATING MULTIPLE MYELOMA AND MYELOMA-INDUCED BONE RESORPTION USING INTEGRIN ANTAGONISTS |
摘要 |
Antagonists of alpha4 integrin/alpha4 integrin ligand adhesion, which inhibit the biological effects of such adhesion are described and methods for their use are detailed. Such antagonists are useful in suppressing bone destruction associated with multiple myeloma. The homing of multiple myeloma cells to bone marrow and their alpha4 integrin-dependent release of bone-resorbing factors, resulting in bone destruction in patients with multiple myeloma, is inhibited. |
申请公布号 |
HU229038(B1) |
申请公布日期 |
2013.07.29 |
申请号 |
HU20010003630 |
申请日期 |
1999.09.13 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
MUNDY, GREGORY R.;YONEDA, TOSHIYUKI |
分类号 |
A61K38/17;C12N15/09;A61K38/00;A61K39/395;A61K45/00;A61P19/00;A61P35/00;C07K14/705;C07K16/18;C07K16/28 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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