FINE GRANULES HAVING IMPROVED CHARACTERISTICS IN WATER SUSPENSION

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: there are described fine granules containing cefcapene pivoxil hydrochloride wherein cefcapene pivoxil hydrochloride particles are coated with a hydrophobic substance, preferentially hydrogenated oil. The fine granules also contain silicone dioxide and a surfactant having a melting point 30°C or more. Preferentially, as a surfactant, the fine granules contain polyoxyethylene(160)polyoxypropylene(30)glycol.EFFECT: invention provides improved water affinity of the fine granules, and the improved characteristics of the water suspension of the fine granules of cefcapene pivoxil hydrochloride.14 cl, 5 dwg, 8 tbl, 9 ex