| 摘要 |
<p>PURPOSE: A biocompatible particle and a method for preparing the same are provided to show a stable sustained release pattern and excellent storage stability. CONSTITUTION: A biocompatible particle is formed by encapsulating nanoparticles containing a drug in a liposome. A (poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) (PEO-PPO-PEO) copolymer is associated on the surface of the liposome. A method for preparing the biocompatible particle comprises the steps of: mixing the drug with one or more kinds of polymers selected among the PEO-PPO-PEO copolymer, poly (lactide-co-glycolide) (PLGA), poly caprolactone (PCL), poly (lactic acid) (PLA), poly (glycolic acid) (PGA), polyethylene glycol, and polysorbate and preparing nanoparticles; mixing the nanoparticles with a liposome solution to prepare a nanoparticle-encapsulated liposome; and mixing the liposome and the PEO-PPO-PEO copolymer solution and freeze-drying the mixture. [Reference numerals] (AA) Liposome; (BB) Nanoparticles; (CC) Liposome particles; (DD) PEO-PPO-PEO copolymer</p> |
