LCLRP peptides, constructs and uses thereof

摘要

NZ 586074 Disclosed is a peptide consisting of a first segment (A) selected from the group of peptides consisting the amino acid sequence of any one of: LCLRP (SEQ ID NO 1); LCLRPVG (SEQ ID NO 2); LCLRPVGAESRGRPV (SEQ ID NO 90); LCLRPVGAESRGRPVSGPFG (SEQ ID NO 6); LCLRPVGAESRGRPVSGPF (SEQ ID NO 71); LCLRPVGAESRGRPVSGP (SEQ ID NO 70); LCLRPVGAESRGRPVSG (SEQ ID NO 69); LCLRPVGAESRGRPVS (SEQ ID NO 68); LCLRPVGAESRGRPV (SEQ ID NO 67); LCLRPVGAESRGRP (SEQ ID NO 66); LCLRPVGAESRG (SEQ ID NO 65); LCLRPVGAER (SEQ ID NO 64); MAARLCCQLDPARDVLCLRP (SEQ ID NO 3); or a functionally equivalent variant of any one thereof; and optionally a second segment (B) connected to the first segment and comprising one or more heterologous amino acids such that the peptide is a fusion peptide. The disclosed peptide is used for increasing the cell membrane permeability of a compound.