发明名称 |
METHODS TO IDENTIFY MACROMOLECULE BINDING AND AGGREGATION PRONE REGIONS IN PROTEINS AND USES THEREFOR |
摘要 |
The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. Similarly, substitutions may then be made in these macromolecule binding regions to engineer proteins with altered binding affinity for the macromolecule. |
申请公布号 |
PT2310970(E) |
申请公布日期 |
2013.07.26 |
申请号 |
PT20090767827T |
申请日期 |
2009.06.19 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;NOVARTIS AG |
发明人 |
NARESH CHENNAMSETTY;BERNHARD HELK;BERNHARDT TROUT;VEYSEL KAYSER;VLADIMIR VOYNOV |
分类号 |
G06F19/16;G06F19/00;G06F19/24 |
主分类号 |
G06F19/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|