| 摘要 |
<p>Disclosed herein is a crystalline solid form of (S)-4-((2S,3S)-7-carbamoyl-1,1-diethyl-3-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylamino)-2-cyclohexylmethyl-butyric acid (compound of formula I) or a crystalline hydrochloride salt of (S)-4-((2S,3S)-7-carbamoyl-1,1-diethyl-3-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylamino)-2-cyclohexylmethyl-butyric acid, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful as mu opioid receptor antagonists and as such are useful for treating or ameliorating medical conditions such as opioid-induced bowel dysfunction or post-operative ileus, a disorder of reduced motility of the gastrointestinal tract, side effects associated with use of an opioid agent in a mammal.</p> |
