发明名称 |
METHODS AND COMPOSITIONS RELATED TO IMMUNIZING AGAINST STAPHYLOCOCCAL LUNG DISEASES AND CONDITIONS |
摘要 |
Embodiments of the invention include methods and compositions useful in a vaccination strategy capable of neutralizing Hla to provide immunoprotection against S. aureus pneumonia. In certain aspects the invention includes a Hla with reduced toxicity, represented by a recombinant mutant form of Hla (HlaH35L) in which histidine 35 is convened to leucine, which can be used to abrogate the productive assembly of the toxin and protect a subject from staphylococcal pneumonia.
|
申请公布号 |
US2013189249(A1) |
申请公布日期 |
2013.07.25 |
申请号 |
US201313742155 |
申请日期 |
2013.01.15 |
申请人 |
UNIVERSITY OF CHICAGO;UNIVERSITY OF CHICAGO |
发明人 |
BUBECK-WARDENBURG JULIANE;SCHNEEWIND OLAF |
分类号 |
C07K16/12;A61K39/40;A61K45/06 |
主分类号 |
C07K16/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|