发明名称 |
USE OF FATOSTATIN FOR TREATING CANCER HAVING A p53 MUTATION |
摘要 |
<p>Fatostatin, a recently described inhibitor of SREBP activation, significantly reduces the level of mutant p53 binding to the HMG-CoA reductase gene promoter. Further, fatostatin treatment had a dramatic effect on normalizing the abnormal 3D morphology of 3 strains of breast cancer cells: MDA-468 cells, MDA-231 cells, and SKBR3 cells. The results show a functional interaction with SREBPs as being critical for mutant p53-mediated upregulation of the mevalonate pathway genes. At a clinical level, inhibition of the mevalonate pathway, either alone or in combination with other therapies, offers a novel, safe and much needed therapeutic option for tumors bearing mutant p53.</p> |
申请公布号 |
WO2013110007(A1) |
申请公布日期 |
2013.07.25 |
申请号 |
WO2013US22326 |
申请日期 |
2013.01.18 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;FREED-PASTOR, WILLIAM;PRIVES, CAROL;OSBORNE, TIMOTHY |
发明人 |
FREED-PASTOR, WILLIAM;PRIVES, CAROL;OSBORNE, TIMOTHY |
分类号 |
G01N33/48;G01N33/53 |
主分类号 |
G01N33/48 |
代理机构 |
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