发明名称 |
METHODS OF INCREASING EFFICIENCY OF VECTOR PENETRATION OF TARGET TISSUE |
摘要 |
Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the interaction of the serum protein galectin 3 binding protein (G3BP) with AAV vector. Further provided are methods for reducing tissue distribution of a virus or for neutralizing a virus harbored by an organ destined for transplant, or newly transplanted, by administering a composition comprising G3BP.
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申请公布号 |
US2013189225(A1) |
申请公布日期 |
2013.07.25 |
申请号 |
US201113636596 |
申请日期 |
2011.03.22 |
申请人 |
VOIT THOMAS;GARCIA LUIS;DENARD JEROME;SVINARTCHOUK FEDOR;ASSOCIATION INSTITUT DE MYOLOGIE;UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;GENETHON |
发明人 |
VOIT THOMAS;GARCIA LUIS;DENARD JEROME;SVINARTCHOUK FEDOR |
分类号 |
A61K48/00;A61K31/522;A61K38/00;A61K38/21 |
主分类号 |
A61K48/00 |
代理机构 |
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