Real-Time Biomechanical Dosimetry using Optical Coherence Elastography

摘要

Methods for quantifying, adjusting or terminating a dose of a therapeutic intervention applied to tissue of a patient. A therapeutic intervention of a specified intensity is applied to a region of interest of the tissue. The tissue is mechanically excited, typically concurrently with the therapeutic intervention, and the region of interest is scanned optically or ultrasonically at the same time. An interference signal is acquired by coherently detecting post-interaction illumination arising in the region of interest by interfering the post-interaction illumination with a reference beam derived from the identical source as that of the scanning. A phase and/or amplitude of response of the tissue relative to the mechanical excitation based on the interference signal. A spatially resolved measure of a property of the region of interest is derived based on the phase of response, allowing for adjustment or termination of the therapeutic intervention.