| 摘要 |
An autologous cancer cell vaccine comprises cancer cells that express both MHCI and MHCII on their cell surface. The MHCI presents a cancer antigen and the MHCII presents a non-self antigen. In accordance with an aspect, there is provided a method for making isolated immunogenic cancer cells, the method comprising: inducing expression of MHCII on cancer cells isolated from a subject; incubating the cancer cells with a non-self antigen so that the non-self antigen will be bound to expressed MHCII; and killing the cancer cells. |
