USE OF CELLULAR BIOMARKERS EXPRESSION TO DIAGNOSE SEPSIS AMONG INTENSIVE CARE PATIENTS

摘要

This invention relates to the area of diagnosis. In particular, it relates to diagnosis and/or risk assessment of sepsis. The present invention proposes the analysis of the surface expression of i) a particular CD16 epitope, ii) surface or intracellular expression of the Toll-Like Receptors 2 and/or 4, iii) the CD24 polypeptide, and/or iv) the CD64 polypeptideas diagnosis tools for early discrimination between patients with sterile systemic inflammatory response syndrome (SIRS) from those who develop sepsis in Intensive Care Unit (ICU).