发明名称 |
COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS |
摘要 |
A compound is represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and the claims. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier of excipient. A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of inhibiting or reducing the activity of HCV polymerase in a subject or in a biological in vitro sample comprises administering to the subject or to the sample a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
|
申请公布号 |
US2013190289(A1) |
申请公布日期 |
2013.07.25 |
申请号 |
US201213723668 |
申请日期 |
2012.12.21 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED;VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
GREEN JEREMY;WILSON DEAN M.;CHAN CHUN KONG LAVAL;DAS SANJOY KUMAR;POISSON CARL;COURT JOHN J.;TANG QING;LI PAN;COLLIER PHILIP N.;WAAL NATHAN;LAUFFER DAVID J.;DORSCH WARREN |
分类号 |
C07D413/12;C07D333/38;C07D409/12 |
主分类号 |
C07D413/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|