PERFUSION BIOREACTOR SYSTEMS AND METHODS OF OPERATING THE SAME

摘要

A perfusion bioreactor system including a cell aggregate trap is provided. The cell aggregate trap is configured to remove cell aggregates (e.g., clumps or aggregates of greater than about 10 cells) from the perfusion bioreactor system. In some embodiments, the cell aggregate trap has a sedimentation chamber and a side flow chamber allowing cell aggregates to settle out and be removed and discarded. Methods of operating the perfusion bioreactor system having a cell aggregate trap are provided, as are numerous other embodiments.