| 发明名称 |
INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE |
| 摘要 |
Compounds are disclosed for the treatment, management and prevention of diseases and disorders affecting the bone. Particular compounds are potent inhibitors of Notum Pectinacetylesterase, and are of the formula: wherein E, G, Y, Z, R1, R2, and R3 are defined herein. |
| 申请公布号 |
EP2616471(A1) |
申请公布日期 |
2013.07.24 |
| 申请号 |
EP20110761206 |
申请日期 |
2011.09.13 |
| 申请人 |
LEXICON PHARMACEUTICALS, INC. |
发明人 |
BARBOSA, JOSEPH;CARSON, KENNETH GORDON;GARDYAN, MICHAEL WALTER;HE, WEI;LOMBARDO, VICTORIA;PABBA, PRAVEEN;TARVER, JAMES JR. |
| 分类号 |
C07D495/04 |
主分类号 |
C07D495/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
