发明名称 |
METHOD OF IDENTIFYING MEMBRANE LG SPECIFIC ANTIBODIES AND USE THEREOF FOR TARGETING IMMUNOGLOBULIN-PRODUCING PRECURSOR CELLS |
摘要 |
<p>The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored IgE and which bind to these novel epitopes on the surface of B cells and plasma cells. In addition, the antibodies of the present invention can mediate ADCC and can be useful to deplete those B cells and plasma cells expressing the novel epitopes of the invention. The antibodies of the present invention can be useful for the treatment of IgE-mediated diseases. Accordingly the present invention also provides compositions and methods for the prevention, management, treatment or amelioration of IgE-mediated diseases.</p> |
申请公布号 |
EP1941275(B1) |
申请公布日期 |
2013.07.24 |
申请号 |
EP20060815598 |
申请日期 |
2006.09.28 |
申请人 |
MEDIMMUNE, INC. |
发明人 |
WU, HERREN;KIENER, PETER;CHOWDHURY, PARTHA, S.;YOUNG, JAMES, F. |
分类号 |
A61K39/00;A61K39/395;C07H21/04;C07K16/00;C07K16/42;C12N15/85;G01N33/569 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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