| 摘要 |
It is intended to disclose a method of identifying a candidate for a remedy of acute myeloid leukemia which comprises contacting activated mutant FLT3 with Lyn in the presence of a test substance and examining whether or not the test substance inhibits the binding of activated mutant FLT3 to Lyn and/or whether or not the test substance inhibits the phosphorylation of Lyn in a cell expressing activated mutant FLT3. It is also intended to disclose a method of identifying a candidate for a remedy of acute myeloid leukemia which comprises contacting a test substance with a cell expressing Lyn and examining whether or not the test substance inhibits the expression or Lyn and/or whether or not the test substance inhibits the phosphorylation of STAT5 by Lyn. A substance identified by the above method is useful as the active ingredient of a remedy for acute myeloid leukemia. |
