发明名称 |
Conjugates comprising a biodegradable polymer and uses therefor |
摘要 |
<p>The present invention provides biologically active agents covalently linked to a polymer. The polymer is preferably a biodegradable polymer. The biologically active agent is preferably a protein, such as an extracellular soluble protein, e.g., an extracellular enzyme. The enzyme can be an apyrase, e.g., NTP-Dase. Conjugates of the invention can be used as therapeutics in subjects. For example, a conjugate comprising an apyrase can be used for treating and preventing thrombosis, atherosclerotic plaque complications and vascular disorders.</p> |
申请公布号 |
EP2138575(B8) |
申请公布日期 |
2013.07.24 |
申请号 |
EP20090011078 |
申请日期 |
2003.02.19 |
申请人 |
MERSANA THERAPEUTICS, INC.;BETH ISRAEL DEACONESS MEDICAL CENTER, INC. |
发明人 |
ELMALEH, DAVID, R.;ROBSON, SIMON, C.;PAPISOV, MIKHAIL, I. |
分类号 |
C12N9/96;A61K31/74;A61K38/46;A61K47/48;C07K1/00;C08L59/00;C12N9/00;C12N9/14;C12N11/02;C12N11/08;C12N11/10;C12N11/12 |
主分类号 |
C12N9/96 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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