发明名称 |
SERPIN-FINGER FUSION POLYPEPTIDE |
摘要 |
The current invention comprises a fusion polypeptide comprising a serpin-finger polypeptide conjugated to a biologically active polypeptide optionally via a peptidic linker polypeptide. Another aspect is a protein complex of the serpin-finger fusion polypeptide and a serpin, wherein the fusion polypeptide is incorporated in the serpin into the middle of beta-sheet A as strand 4a. Also an aspect of the current invention is the in vitro preparation of the protein complex. The serpin-finger polypeptide targets and anchors the biologically active polypeptide with high affinity and functional spatial orientation. |
申请公布号 |
EP2616487(A1) |
申请公布日期 |
2013.07.24 |
申请号 |
EP20110757847 |
申请日期 |
2011.09.13 |
申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
ENGH, RICHARD;KOPETZKI, ERHARD;SCHLOTHAUER, TILMAN |
分类号 |
C07K14/81;C07K14/16;C12N15/62 |
主分类号 |
C07K14/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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