DRUG DELIVERY SYSTEM PREPARED WITH AMPHIPHILIC ADHESIVE

摘要

PURPOSE: A drug delivery system is provided to selectively and easily allow bacteria to adhere onto a specific layer by comprising a hydrophilic biodegradable polymer layer and a hydrophobic biodegradable polymer layer. CONSTITUTION: A drug delivery system comprises a hydrophilic biodegradable polymer layer (100) and a hydrophobic biodegradable polymer layer (111). Bacteria adhere onto the surface of one layer among the biodegradable polymer layers. A drug is contained in the biodegradable polymer layer in which bacteria did not adhere. The hydrophilic biodegradable polymer contains one or more ingredients selected from alginate or a derivative thereof, chitosan or a derivative thereof, hyaluronic acid or a derivative thereof, gelatin, collagen, polyethylene glycol (PEG), and polyvinylpyrrolidone (PVP). The hydrophobic biodegradable polymer contains one or more ingredients selected from poly-caprolactone, L-poly-lactides (LPLA), poly-glycolic acid (PGA), poly-D-lactide (PDLA), poly-lactic acid (PLA), and poly-lactic-co-glycolic acid (PLGA). [Reference numerals] (100) Hydrophobic polymer layer; (110) Amphiphilic adhesive material; (111) Hydrophilic polymer layer containing a drug