PRODUCTION METHOD FOR CHEMICALS BY CONTINUOUS FERMENTATION

摘要

In the production and collection of a product through fermentation using a separation membrane, it becomes possible to retain filter performance for the high-concentration culturing of a microbe mixture, and at the same time control microbe concentrations, by a method for producing chemicals through continuous fermentation, including washing a membrane with a washing liquid supplied from a permeate side of a membrane unit in a continuous fermentation including: filtering a culture medium containing a fermentation feedstock, a chemical and a microbe or a cultured cell through a separation membrane; collecting the chemical from a filtrate; retaining or refluxing unfiltered remains in the culture medium; and adding a fermentation feedstock to the culture medium, in which the washing liquid is high-temperature water having a temperature higher than a temperature of the culture medium and of 150°C or less, and a concentration of the microbe in a fermenter is controlled by supplying the washing liquid.