High arachidonic acid producing strains of yarrowia lipolytica
摘要
Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 10% arachidonic acid (ARA, an É-6 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases, and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of ARA. Production host cells are claimed, as are methods for producing ARA within said host cells.
申请公布号
EP2458000(B1)
申请公布日期
2013.07.24
申请号
EP20120152258
申请日期
2005.11.03
申请人
E. I. DU PONT DE NEMOURS AND COMPANY
发明人
DAMUDE, HOWARD G.;MACOOL, DANIEL JOSEPH;PICATAGGIO, STEPHEN K.;POLLAK, DANA M. WALTERS;RAGGHIANTI, JAMES JOHN;XUE, ZHIXIONG;YADAV, NARENDRA S.;ZHANG, HONGXIANG;ZHU, QUINN QUN