发明名称 |
MODIFIED iRNA AGENTS |
摘要 |
The present invention provides effective motifs for RNA agents conjugated to at least one ligand, which are advantageous for the in vivo delivery of iRNA duplex agents. Additionally, the present invention provides methods of making these compositions, as well as methods of introducing these iRNA duplex agents into cells using these compositions, e.g., for the treatment of various disease conditions. |
申请公布号 |
EP2616543(A1) |
申请公布日期 |
2013.07.24 |
申请号 |
EP20110767103 |
申请日期 |
2011.09.14 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
RAJEEV, KALLANTHOTTATHIL, G.;ZIMMERMANN, TRACY;MANOHARAN, MUTHIAH;MAIER, MARTIN;FITZGERALD, KEVIN |
分类号 |
C12N15/113;A61K31/713;C07H21/00;C12N15/87 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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