发明名称 |
Analgesia with minimal tolerance and dependence by a mu opioid receptor agonist that also binds filamin A |
摘要 |
A composition and method are disclosed that utilize an isolated polypeptide or analog thereof to inhibit the interaction of a mu-opioid receptor with filamin A. A contemplated polypeptide has an amino acid residue sequence illustrated by the formula: W-[X1X2X3- . . . X43X44X45]nValAlaX48GlyLeu[X51X52X53 . . . X94X95X96]m-Y, wherein the various elements are defined elsewhere. A contemplated method can be used to select a VAKGL-binding compound.
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申请公布号 |
US8492349(B2) |
申请公布日期 |
2013.07.23 |
申请号 |
US201213408734 |
申请日期 |
2012.02.29 |
申请人 |
WANG HOAU-YAN;BURNS BARBIER LINDSAY;WANG JIAN;PAIN THERAPEUTICS, INC. |
发明人 |
WANG HOAU-YAN;BURNS BARBIER LINDSAY;WANG JIAN |
分类号 |
A61K38/08 |
主分类号 |
A61K38/08 |
代理机构 |
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代理人 |
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地址 |
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