AQUEOUS DISPERSION OF ORGANIC NANO-PHOTOSENSITIZER CONTAINING HEAVY-ATOMIC DISPERSING AGENT, AND PREPARATION METHOD AND USE THEREOF

摘要

PURPOSE: A method for preparing near infrared photosensitizer organic nanoparticles of aqueous dispersion and a photodynamic therapeutic agent containing the same are provided to ensure low toxicity and to induce cancer cell apoptosis in vivo or in vitro. CONSTITUTION: A nano-photosensitizer of aqueous dispersion contains: a core with a photosensitizer; bio-affinity polymers covering the core; and water. The core further comprises a heavy-atomic dispersion agent corresponding to the photosensitizer. The heavy-atomic dispersion agent is a hydrophobic molecule containing iodine or heavy metals. The wavelength of the photosensitizer is 500-900 nm. A photodynamic therapeutic agent contains the nano-photosensitizer.