| 发明名称 |
MIR-21 promoter driven targeted cancer therapy |
| 摘要 |
The invention provides a nucleic acid construct comprising a promoter sequence derived from microRNA-21 (miR-21) linked to a nucleic acid sequence encoding an anti-cancer agent, an example of which is a toxin. The constructs of the invention are particularly useful for treating tumors expressing miR-21.
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| 申请公布号 |
US8492133(B2) |
申请公布日期 |
2013.07.23 |
| 申请号 |
US201013145332 |
申请日期 |
2010.01.19 |
| 申请人 |
ROSIN-ARBESFELD RINA;SKLAN ELLA;ZILBERBERG ALONA;DAVID NAAMA;RAMOT AT TEL AVIV UNIVERSITY, LTD. |
发明人 |
ROSIN-ARBESFELD RINA;SKLAN ELLA;ZILBERBERG ALONA;DAVID NAAMA |
| 分类号 |
C12N15/85 |
主分类号 |
C12N15/85 |
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