发明名称 |
USE OF TRANSCRIPTOME-MODIFYING AGENTS AND CHEMOTHERAPY OR RADIOTHERAPY AGAINST CANCER |
摘要 |
<p>The invention relates to the use of transcriptome-modifying agents in order to prevent malignant cells from undergoing the necessary genetic changes in order to combat cell insult and survive chemotherapy or radiotherapy. Said combination of transcriptome-modifying agents comprises agents that inhibit the DNA methylation machinery plus a substance that inhibits histone deacetylation. The invention relates to a treatment kit which involves the administration of an effective dose of hydralazine and valproic acid or a salt of same in the case of magnesium valproate, which is intended for use with radiotherapy or chemotherapy in the treatment of patients cancer.</p> |
申请公布号 |
CA2630334(C) |
申请公布日期 |
2013.07.23 |
申请号 |
CA20052630334 |
申请日期 |
2005.11.16 |
申请人 |
UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO |
发明人 |
DUENAS GONZALEZ, ALFONSO;ESTRADA FLORES, LUIS |
分类号 |
A61K31/19;A61K31/502;A61P35/00 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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