| 摘要 |
PROBLEM TO BE SOLVED: To provide compounds, compositions and methods for more controlling over the therapeutic effect, pharmacokinetics and duration of activity of nucleic acid ligands in the method for using the nucleic acid ligands in medical therapy.SOLUTION: The biological activity of a nucleic acid ligand is regulated (i.e. enhanced or inhibited) in vivo to produce a desired biological effect by administering a modulator, or regulator that changes the binding of the nucleic acid ligand for its target or degrades or otherwise cleaves, metabolizes or breaks down the nucleic acid ligand while the ligand is still exerting its effect. |
