| 摘要 |
PROBLEM TO BE SOLVED: To provide new glycosylated peptide target in neoplastic cells.SOLUTION: There are provided polypeptide, nucleic acid and other compositions. Polypeptide, nucleic acid and other compositions are useful in treatment and diagnostic methods. One treatment method includes inhibiting growth or proliferation of hyperproliferative cells, or inducing regression of hyperproliferative cells, such as cells of a cellular hyperproliferative disorder, or reducing levels of LDL or oxLDL. In one embodiment, isolated and purified glycoprotein denoted as a SAM-6 Receptor (SAM-6/R), or a SAM-6/R glycoprotein are provided. In another embodiment, a SAM-6/R glycoprotein has an apparent molecular weight in a range of about 80-82 kilodaltons (kDa) as determined by denaturing gel electrophoresis, at least one nitrogen (N)- or oxygen (O)-linked carbohydrate moiety distinct from Grp78, and an antibody denoted SAM-6 specifically binds to the SAM-6/R glycoprotein. |
