发明名称 A cross linking polypeptide comprising an hexameric single chain antibody binding MHC-MAGE complex that induces apoptosis
摘要 The present invention relates to a polypeptide comprising at least four domains specifically binding to a certain MHC peptide complex, said domains separated by linker amino acid sequences, thereby providing each domain with the capability to bind a separate MHC peptide complex, to a nucleic acid encoding for such a polypeptide, to a vector comprising such a nucleic acid, to a host cell for expression of such a polypeptide, to a pharmaceutical composition comprising such a polypeptide, and to a kit of parts comprising at least two polypeptides according to the invention.
申请公布号 AU2011353197(A1) 申请公布日期 2013.07.18
申请号 AU20110353197 申请日期 2011.12.22
申请人 APO-T B.V. 发明人 WILLEMSEN, RALPH ALEXANDER
分类号 C07K16/28;A61K39/395;A61P35/00;C07K16/30 主分类号 C07K16/28
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