发明名称 |
METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS |
摘要 |
Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU prodrug is in substantial excess of DPD inhibitor in the patient.
|
申请公布号 |
US2013184232(A1) |
申请公布日期 |
2013.07.18 |
申请号 |
US201213686240 |
申请日期 |
2012.11.27 |
申请人 |
SPECTOR THOMAS;PETERS WILLIAM PAUL;KUFE DONALD W.;HUBER BRIAN |
发明人 |
SPECTOR THOMAS;PETERS WILLIAM PAUL;KUFE DONALD W.;HUBER BRIAN |
分类号 |
A61K31/513 |
主分类号 |
A61K31/513 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|