发明名称 |
ABERRANT CELL-RESTRICTED IMMUNOGLOBULINS PROVIDED WITH A TOXIC MOIETY |
摘要 |
<p>Described are immunoglobulins provided with a toxic moiety, comprising at least an immunoglobulin variable region that specifically binds to an MHC-peptide complex preferentially associated with aberrant cells. These immunoglobulins provided with a toxic moiety are preferably used in selectively modulating biological processes. The provided immunoglobulins provided with a toxic moiety are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers and autoimmune diseases.</p> |
申请公布号 |
CA2860914(A1) |
申请公布日期 |
2013.07.18 |
申请号 |
CA20132860914 |
申请日期 |
2013.01.11 |
申请人 |
APO-T B.V. |
发明人 |
RENES, JOHAN;STEVERINK, PAUL;WILLEMSEN, RALPH ALEXANDER |
分类号 |
A61K47/48;C07K16/30 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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