A MICROORGANISM OF ESCHERICHIA COLI GENUS HAVING ENHANCED L-TRYPTOPHAN PRODUCING ACTIVITY AND METHOD FOR PRODUCING L-TRYPTOPHAN USING THE SAME

摘要

PURPOSE: Escherichia species microorganism with reinforced L-tryptophan production is provided to solve excessive accumulation phenomenon of anthranilate and to be able to be usefully used in producing L-tryptophan with a high yield. CONSTITUTION: A recombinant Escherichia species microorganism with reinforced L-tryptophan production is that the entire or a part of leader peptide having the base sequence of Sequence no. 2 is lost in the expression control region having the base sequence of Sequence no. 1 in the immanent tryptophan operon. A production method of L-tryptophan comprises a step of cultivating recombinant Escherichia species microorganism with reinforced L-tryptophan production which is manufactured by deleting the entire or a part of leader peptide having the base sequence of Sequence no. 2 in the expression control region having the base sequence of Sequence no. 1 in the immanent tryptophan operon. [Reference numerals] (A) Damping control factor; (AA) Tryptophan operon; (L) Leader peptide; (P) Promoter