发明名称 |
siRNA for inhibition of Hif1alpha expression and anticancer composition containing the same |
摘要 |
Disclosed are small interfering RNA (siRNA) that complementarily binds to a base sequence of Hif1α mRNA transcript, thereby inhibiting expression of Hif1α without inducing immune responses, and a use of the siRNA for prevention and/or treatment of cancer. Since Hif1α is commonly overexpressed in almost all cancer cells, the siRNA that complementarily binds to Hif1α-encoding mRNA may inhibit expression of Hif1α through RNA-mediated interference (RNAi), thereby inhibiting proliferation and metastasis of cancer cells, and thus, the siRNA may be useful as an anticancer agent. |
申请公布号 |
AU2011353283(A1) |
申请公布日期 |
2013.07.18 |
申请号 |
AU20110353283 |
申请日期 |
2011.12.29 |
申请人 |
SAMYANG BIOPHARMACEUTICALS CORPORATION |
发明人 |
KIM, SUN-OK;KIM, SANG-HEE;CHO, EUN-AH;IN, CHANG-HOON |
分类号 |
A61K31/7105;A61K48/00;A61P35/00;C12N15/113 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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