发明名称 |
METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF THE INTERLEUKIN-35 RECEPTOR COMPLEX |
摘要 |
The receptor for Interleukin 35 (IL-35) is provided. The Interleukin 35 Receptor (IL-35R) comprises a heterodimeric complex of the Interluekin12Rbeta2 receptor and the gp130 receptor. Various compositions comprising the IL-35R complex, along with polynucleotides encoding the same and kits and methods for the detection of the same the same are provided. Methods of modulating the activity of IL-35R or modulating effector T cell functions are also provided. Such methods employ various IL-35R antagonists and agonists that modulate the activity of the IL-35R complex and, in some embodiments, modulate effector T cell function. Further provided are methods for screening for IL-35R binding agents and for IL-35R modulating agents. Various methods of treatment are further provided.
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申请公布号 |
US2013183326(A9) |
申请公布日期 |
2013.07.18 |
申请号 |
US201013509072 |
申请日期 |
2010.11.19 |
申请人 |
VIGNALI DARIO AA;COLLISON LAUREN W.;ST. JUDE CHILDREN'S RESEARCH HOSPITAL |
发明人 |
VIGNALI DARIO AA;COLLISON LAUREN W. |
分类号 |
A61K38/17;A01K67/027;A61K39/00;A61P29/00;A61P35/00;C07H21/04;C07K14/715;C07K16/18;C12N5/10;C12Q1/68;G01N33/53;G01N33/566 |
主分类号 |
A61K38/17 |
代理机构 |
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