Fulvestrant nanosphere/microsphere and preparative method and use thereof

摘要

Fulvestrant nanosphere/microsphere and preparative method and use thereof are provided in the present invention. The carrier material of the fulvestrant nanosphere /microsphere is methoxy ended polyethylene glycol-polylactic acid block copolymer. The nanosphere/microsphere is prepared by solvent-nonsolvent method, liquid drying method and/or spray drying method, and has the features of high medicine carrying quantity and high envelop rate, controllable release of medicine and no irritant to application site or blood vessel. The fulvestrant nanosphere/microsphere is used to treat metastatic advanced breast cancer in post-menopausal woman.