| 摘要 |
PROBLEM TO BE SOLVED: To provide an oral osmotic pressure drug delivery system capable of overcoming a delivery fault in a drug that is highly water-soluble but has a problem with its release from an osmotic pressure dosage form.SOLUTION: There is provided an oral osmotic pressure drug delivery system that includes, when formulating by a standard osmotic pressure delivery system, a highly water-soluble drug showing an irregular or incomplete release profile and at least one release promoter. It is desirable that a water-solubility of the drug is at least 30 mg/ml. It is desirable that the drug is prostacyclin, especially treprostinil. It is desirable that the release promoter is selected from a group of wicking medicine, complexing agent, and micelle formation medicine. It is desirable that the wicking medicine is selected from a group including a surfactant and a non-swelling hydrophilic polymer. It is desirable that the non-swelling hydrophilic polymer is polyethylene glycol or the like, the complexing agent is polyvinylpyrrolidone or the like, and the micelle formation medicine is fatty acid sorbitan ester or the like. |
