| 发明名称 |
SUSTAINED RELEASE FORMULATION OF METHOTREXATE AS A DISEASE-MODIFYING ANTIRHEUMATIC DRUG (DMARD) AND AN ANTI-CANCER AGENT |
| 摘要 |
Disclosed is are formulations comprising a multivesicular liposome and MTX, the administration of which results in a Cmax of MTX between 5% and 50% of the Cmax of an immediate release dosage form of MTX, the duration of which lasts from about 1 to about 30 days. Also disclosed are methods of treating autoimmune diseases and cancer by administering these formulations of MTX.
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| 申请公布号 |
US2013183370(A1) |
申请公布日期 |
2013.07.18 |
| 申请号 |
US201313786323 |
申请日期 |
2013.03.05 |
| 申请人 |
PACIRA PHARMACEUTICALS, INC.;PACIRA PHARMACEUTICALS, INC. |
发明人 |
GARCIA LOUIE DANIEL;GIBSON LOIS;LAMBERT WILLIAM JOSEPH;LI BENJAMIN W.;ZHU LIANGJIN |
| 分类号 |
A61K9/127 |
主分类号 |
A61K9/127 |
| 代理机构 |
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