发明名称 |
NOVEL GENE VACCINATION LIPOSOMES |
摘要 |
<p>The present invention relates to liposomes composed of DOPE and/or of a variant of DOPE bearing at least one ligand for targeting dendritic cells, of DOTAP and/or of a variant of DOTAP bearing at least one ligand for targeting dendritic cells and of cardiolipin and/or of a variant of cardiolipin bearing at least one ligand for targeting dendritic cells; and to the use thereof as a genetic material carrier for preparing lipoplexes. The lipoplexes according to the invention are advantageous because of the limited cytotoxicity thereof in vivo; they are therefore of particular interest for gene vaccination; in a form encapsulated in a biodegradable and nonimmunogenic cell such as an alginate gel, they are particularly suitable in particular for oral vaccination of aquatic animals.</p> |
申请公布号 |
EP2613768(A1) |
申请公布日期 |
2013.07.17 |
申请号 |
EP20110764867 |
申请日期 |
2011.09.09 |
申请人 |
CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHEAGRONOMIQUE POUR LE DEVELOPPEMENT;INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA (INIA) |
发明人 |
MOCKEY, MICHAEL;DEDIEU, LAURENCE;TAFALLA, CAROLINA;CUESTA, ALBERTO |
分类号 |
A61K9/127;A61K9/00;A61K47/48;A61K48/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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