发明名称 |
Method for identifying compounds which inhibit binding of anthrax protein to LRP5/6 receptors |
摘要 |
The present invention identifies compounds that disrupt the interaction between anthrax proteins and LRP5/6 receptors, resulting in a reduction in anthrax toxicity. The compounds act to disrupt the intracellular transport of toxin complexes into a target cell. The present invention also provides methods for testing the effect of compounds on Wnt activity, through the use of in vitro experiments involving cells that have in at least one gene mutation involved in the Wnt pathway. |
申请公布号 |
EP2615456(A1) |
申请公布日期 |
2013.07.17 |
申请号 |
EP20120185412 |
申请日期 |
2009.08.14 |
申请人 |
ENZO BIOCHEM, INC. |
发明人 |
LIU, DAKAI;JIN, RICHARD;LI, XIAOFENG;ZHANG, YAZHOU;CHENG, WEI;BHATTACHARYYA, RIDDHI |
分类号 |
G01N33/53;G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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