The invention pertains to modifications for antisense oligonucleotides, wherein the modifications are used to improve stability and provide protection from nuclease degradation. The modifications could also be incorporated into double-stranded nucleic acids, such as synthetic siRNAs and miRNAs.
申请公布号
EP2614149(A1)
申请公布日期
2013.07.17
申请号
EP20110760620
申请日期
2011.09.07
申请人
INTEGRATED DNA TECHNOLOGIES, INC.
发明人
BEHLKE, MARK, AARON;OWCZARZY, RICHARD;YOU, YONG;WALDER, JOSEPH, ALAN;LENNOX, KIM
