BIOTINYLATED POLYSACCHARIDES HAVING AN ANTITHROMBOTIC ACTIVITY AND IMPROVED METABOLIC STABILITY

摘要

The invention relates to novel polysaccharides with an antithrombotic activity, having at least one covalent bond with biotin or a biotin derivative, wherein said covalent bond is resistant to metabolic cleavage and comprises a linkage X selected from the group consisting of -O-, -N(R)-, -N(R)-CO- and -N(R')-CO-N(R'')-, wherein R is an alkyl group and R' and R'', which may be identical or different, are, independently of one another, a hydrogen atom or alkyl group.