发明名称 |
PROCESS FOR PRODUCING REVEROMYCIN A OR A SYNTHETIC INTERMEDIATE THEREOF, PROCESS FOR PRODUCING COMPOUNDS CONTAINING A SPIROKETAL RING AND NOVEL ANTINEOPLASTICS, FUNGICIDES AND THERAPEUTIC AGENTS FOR BONE DISORDERS |
摘要 |
A bacterium belonging to the genus Streptomyces having an ability to produce reveromycin A or a synthetic intermediate thereof, the bacterium being modified so as to increase expression of revQ gene coding for the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence having an identity of not less than 80% to SEQ ID NO: 36 as compared with a parent strain, thereby the above-mentioned production ability is increased as compared with the parent strain. |
申请公布号 |
EP2615168(A1) |
申请公布日期 |
2013.07.17 |
申请号 |
EP20110821826 |
申请日期 |
2011.08.30 |
申请人 |
RIKEN |
发明人 |
OSADA, HIROYUKI;TAKAHASHI, SHUNJI;KAWATANI, MAKOTO;SANAKI, YOSHIYUKI;TOYODA, ATSUSHI |
分类号 |
C07K14/36;A61K31/351;C07D493/10;C12N1/21;C12N9/04;C12N15/00;C12N15/09;C12N15/52;C12P7/42;C12P7/50;C12P17/06;C12P17/18 |
主分类号 |
C07K14/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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