发明名称 |
SCREENING METHOD UTILIZING THALIDOMIDE-TARGETING FACTOR |
摘要 |
With an aim to provide means for developing a compound devoid of teratogenicity but retaining beneficial actions, a screening method for a non-teratogenic substance comprising bringing a test substance into contact with cereblon or a fragment of cereblon, evaluating the bindability of the test substance with cereblon or the fragment of cereblon, and selecting a test substance that does not bind to cereblon or the fragment of cereblon or a test substance exhibiting lower bindability with cereblon or the fragment of cereblon than does thalidomide is provided. |
申请公布号 |
EP2492686(A4) |
申请公布日期 |
2013.07.17 |
申请号 |
EP20100824892 |
申请日期 |
2010.10.18 |
申请人 |
TOKYO INSTITUTE OF TECHNOLOGY;FUJIMOTO PHARMACEUTICAL CORPORATION |
发明人 |
HANDA, HIROSHI;ANDO, HIDEKI;ITOH, TAKUMI;HOTTA, KENTARO |
分类号 |
G01N33/566;A01K67/027;C07K14/435;C12N15/09;G01N33/15;G01N33/50 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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