PROCESS FOR PREPARATION OF SUBSTANTIALLY PURE FOSAMPRENAVIR CALCIUM AND ITS INTERMEDIATES
摘要
<p>The present invention relates to fosamprenavir calcium (Ia) substantially free of isomer impurity, (3R) tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propyl carbamate (Ib), and its process for preparation thereof. The present invention also provides fosamprenavir calcium intermediate, (S)-3-tetrahydrofuranyl-N-succinimidyl carbonate (IIa) substantially free of (R)-3-tetrahydrofuranylsuccinimidyl carbonate (IIb) and its process for preparation thereof.</p>
申请公布号
EP2614055(A2)
申请公布日期
2013.07.17
申请号
EP20110770160
申请日期
2011.09.05
申请人
LUPIN LIMITED
发明人
ARORA, SURINDER, KUMAR;SHABADE, SAMIR, SHANTESHWAR;KUMAR, GAURAV;RAY, PURNA, CHANDRA;SINGH, GIRIJ, PAL