发明名称 |
YEAST CELLS EXPRESSING AMYLOID BETA AND USES THEREFOR |
摘要 |
Disclosed are yeast cells expressing a polypeptide comprising a signal sequence and a human amyloid beta protein. Also disclosed are methods of screening yeast cells to identify compounds that prevent or suppress amyloid beta-induced toxicity and genetic suppressors or enhancers of amyloid beta-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as Alzheimer's disease. |
申请公布号 |
EP2524040(A4) |
申请公布日期 |
2013.07.17 |
申请号 |
EP20110733279 |
申请日期 |
2011.01.11 |
申请人 |
THE WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH |
发明人 |
MATLACK, KENT E.S.;LINDQUIST, SUSAN L. |
分类号 |
C12N15/12 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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