发明名称 |
Promoter inducible by reactive oxygen species and vector comprising the same |
摘要 |
The invention provides promoters inducible by reactive oxygen species (ROS), capable of driving the expression of a gene of interest, particularly in a tumor cell. More particularly, it refers to promoters inducible by reactive oxygen species, that may be used to drive the expression of a gene of interest, such as a therapeutic gene, or a reporter gene for use in image diagnosis. The promoter consists of a chimeric promoter containing an E6 element and a VE element. It also provides vectors carrying a human therapeutic or non therapeutic gene of interest, operably linked to said promoter sequence and compositions comprising the same. |
申请公布号 |
EP2615102(A1) |
申请公布日期 |
2013.07.17 |
申请号 |
EP20130151932 |
申请日期 |
2008.04.25 |
申请人 |
INIS BIOTECH LLC;FUNDACION INSTITUTO LELOIR;COMISION NACIONAL DE ENERGIA ATOMICA (CNEA);CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS YTECNICAS (CONICET) |
发明人 |
POLICASTRO, LUCIA;DURAN, HEBE;PODHAJCER, OSVALDO |
分类号 |
C07H21/04;A61K48/00;C12N15/00 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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