发明名称 |
Intramolecularly-quenched near infrared fluorescent probes |
摘要 |
An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
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申请公布号 |
US8486373(B2) |
申请公布日期 |
2013.07.16 |
申请号 |
US20040979755 |
申请日期 |
2004.11.01 |
申请人 |
WEISSLEDER RALPH;TUNG CHING-HSUAN;MAHMOOD UMAR;JOSEPHSON LEE;BOGDANOV ALEXEI;THE GENERAL HOSPITAL CORPORATION |
发明人 |
WEISSLEDER RALPH;TUNG CHING-HSUAN;MAHMOOD UMAR;JOSEPHSON LEE;BOGDANOV ALEXEI |
分类号 |
A61B10/00;A61B5/00;A61B8/00;A61K47/48;A61K49/00;C07K7/06 |
主分类号 |
A61B10/00 |
代理机构 |
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代理人 |
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地址 |
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