发明名称 Process for the preparation of nebivolol
摘要 The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.
申请公布号 US8487122(B2) 申请公布日期 2013.07.16
申请号 US201113578018 申请日期 2011.02.09
申请人 BARTOLI SANDRA;CIPOLLONE AMALIA;FATTORI DANIELA;MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. 发明人 BARTOLI SANDRA;CIPOLLONE AMALIA;FATTORI DANIELA
分类号 C07D311/00 主分类号 C07D311/00
代理机构 代理人
主权项
地址